星球细胞是TNF调解恒常性突触可塑性的来源
Renu Heir1, Zahra Abbasi1, Pragya Komal1
1Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, Research Institute of the McGill University Health Center, Montréal, Quebec H3G 1A4, Canada.
概括
星球细胞是瘤坏死因子-α (TNF) 的必要来源,用于稳态突触可塑性 (HSP). 减少的神经元活动会触发星球细胞释放TNF,驱动HSP.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 已知瘤亡因子-α (TNF) 能够调节家庭静止突触可塑性 (HSP).
- 之前的研究表明,TNF在应对慢性活动阻塞时从质细胞释放出来.
- 在HSP期间负责TNF释放的特定质细胞类型仍未确定.
研究的目的:
- 确定在恒常性突触可塑性 (HSP) 期间负责产生TNF的特定质细胞类型.
- 阐明神经元活动变化的反应中天体细胞TNF产生所涉及的信号通路.
主要方法:
- 使用了老鼠和小鼠海马切片培养物.
- 在星球细胞和微质细胞中采用了微质枯竭和条件TNF删除策略.
- 测量TNF水平和评估TTX驱动的HSP.
- 研究了谷氨酸信号传递和NFκB通路在星球细胞中的作用.
主要成果:
- 微质的枯竭或从微质中删除TNF并没有阻止TTX驱动的HSP.
- 条件删除特异性的TNF从星球细胞取消了TTX驱动的HSP.
- 星细胞谷氨酸信号传递影响了NFκB信号传递和TNF mRNA水平.
- 慢性TTX治疗在星球细胞中以NFκB依赖的方式增加了TNF.
结论:
- 星球细胞是TNF的重要来源,对于恒常性突触可塑性而言,这是必不可少的.
- 星球细胞通过谷氨酸溢出感知到神经元活动减少.
- 星球细胞增加TNF的产生,这驱动HSP,在一个依赖NFκB信号的过程中.
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