在COVID-19疫苗接种后发生的听觉受体不良事件
Aishwarya N Shetty1, Hannah J Morgan2, Linny K Phuong3
1Epi-Informatics group and SAEFVIC, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Victoria, Australia; Epi-Informatics, Centre for Health Analytics, Melbourne Children's Campus, 50 Flemington Road, Parkville, Victoria, Australia.
Vaccine
|February 23, 2024
概括
这项研究发现,mRNA COVID-19疫苗接种后头风险增加,mRNA和腺病毒载体疫苗接种后耳声增加. 听力损失与COVID-19疫苗接种无关.
科学领域:
- 听力学 听力学是指听力学.
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 关于在COVID-19疫苗接种后发生的听觉受体不良事件,有不确的证据.
- 从2021年1月到2023年3月,在澳大利亚东南部进行了一项研究,以调查潜在的关联.
研究的目的:
- 为了确定COVID-19疫苗接种是否与听觉静脉事件的发病率增加有关.
- 分析疫苗安全监督的自发报告和一般实践数据.
主要方法:
- 对自发向SAEFVIC (疫苗安全监督服务) 报告的回顾性观察分析.
- 自主控制的病例系列分析,使用来自POpulation Level Analysis and Reporting (POLAR) 工具的一般实践数据.
主要成果:
- 在mRNA COVID-19疫苗接种后观察到头发病率增加 (相对发病率[RI] = 1.40,P < .001).
- 在接种Vaxzevria® (腺病毒载体) 和mRNA疫苗 (RI = 2.25,P < .001和RI = 1.53,P < .001分别) 后,耳发生率增加.
- 在任何COVID-19疫苗接种后,没有发现听力损失的显著增加.
结论:
- 这项研究是首次将mRNA疫苗与增加的头呈现和两种疫苗类型与耳联系起来.
- 局限性包括无法完全解释并发的COVID-19感染,这些感染已知会导致听觉节事件.
- 医疗保健提供者和患者应该意识到疫苗接种后可能出现的听觉和听觉器官投诉,强调现实数据在公共卫生中的价值.
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