相关实验视频

Updated: Jul 2, 2025

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles

Published on: May 14, 2021

许多面孔,许多地方:深入研究CAF在NSCLC的异质性

Kostas A Papavassiliou¹, Christos Adamopoulos², Athanasios G Papavassiliou³

¹First University Department of Respiratory Medicine, 'Sotiria' Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.

Trends in cancer

|February 23, 2024

概括

研究人员分析了非小细胞肺癌 (NSCLC) 患者的癌症相关纤维细胞 (CAF) 异质性. 他们确定了与患者预后,转移和治疗耐药性相关的独特CAF表型,强调了CAF位置的重要性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

癌症相关纤维细胞 (CAFs) 在瘤微环境中发挥着关键作用.
了解CAF异质性对于开发有效的癌症疗法至关重要.
非小细胞肺癌 (NSCLC) 仍然是全球癌症相关死亡的主要原因.

研究的目的:

研究非小细胞肺癌 (NSCLC) 中癌症相关纤维细胞 (CAF) 的异质性.
定义与临床结果相关的CAF表型,包括预后,转移和化学抵抗.
探索CAF空间位置与NSCLC免疫细胞透之间的相关性.

主要方法:

多重成像质细胞计被用来分析CAF群体.
这项研究包括了1070名NSCLC患者的队列.
对CAF表型及其在瘤微环境中的空间分布进行定量分析.

主要成果:

确定了不同的CAF表型,区分了预后良好和不良的组.
预后不佳的CAF表型与转移和化学抵抗的增加显著相关.
CAF的空间位置与NSCLC患者的免疫细胞透和整体临床结果有相关性.

结论:

CAF异质性是NSCLC临床结果的重要决定因素.
针对特定的CAF表型或它们的空间分布可能提供新的治疗策略.
对不同CAF种群的功能性作用进行进一步的研究是有必要的,以改善NSCLC治疗.

关键词:

与癌症相关的纤维细胞.非小细胞肺癌的肺癌.现象类型现象类型预后预后预后瘤微环境是一个微环境.

更多相关视频

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids

Published on: October 21, 2022

Three-dimensional Co-culture Model for Tumor-stromal Interaction

Three-dimensional Co-culture Model for Tumor-stromal Interaction

Published on: February 2, 2015

相关概念视频

Introduction to Fibroblasts

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...