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Updated: Jul 2, 2025

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对修改的马什和施奈德模型的外部验证,用于目标控制输液麻醉中的中链甘油三基

Seongheon Lee1,2, Dongho Kang1, Eunjin Song1

  • 1Department of Anesthesiology and Pain Medicine, Chonnam University Hospital, Gwangju, South Korea.

BMC anesthesiology
|February 23, 2024
PubMed
概括

修改后的马什和施奈德的药理动力学模型在临床上是可接受的目标控制输注 (TCI) 的propofol与中长链甘油三 (MCT/LCT) 配方. 他们的预测性能对于全身麻醉仍然可靠.

关键词:
外部验证的验证方法马什模型 马什模型这是一种Propofol配方.施奈德的模型模型目标控制输液注入目标控制输注.

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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