在2型糖尿病中检测到的早期冠状腺和视网膜变化及其与糖尿病病的关联:一项纵向前性研究
Monica Oliveira da Silva1,2, Anne Elise Cruz do Carmo Chaves3,4, Glauber Corrêa Gobbato3,5
1Retina and Vitreous Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. cebio.monica@gmail.com.
BMC ophthalmology
|February 23, 2024
概括
2型糖尿病 (T2D) 患有轻度糖尿病视网膜病变或没有糖尿病视网膜病变的患者在视网膜和胸膜中表现出早期的神经血管损伤. 这种损伤进展,与血糖控制和病 (DKD) 标志物相关.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
背景情况:
- 2型糖尿病 (T2D) 与影响视网膜和脏的微血管并发症有关.
- 糖尿病病 (DKD) 是T2D的常见并发症,但其对早期视网膜和胆道变化的影响尚未完全理解.
研究的目的:
- 为了研究T2D患者视网膜和胸膜的结构变化.
- 评估这些结构变化与糖尿病病 (DKD) 的存在和进展之间的关联.
主要方法:
- 在3年内对T2D患者进行轻度或无糖尿病视网膜病变 (DR) 的长度研究.
- 使用结构光谱域光学一致性断层扫描 (SS-OCT) 和OCT血管造影 (OCT-A) 每6个月.
- 基于基线DKD状态的视网膜和胸膜参数进行比较.
主要成果:
- 在T2D患者中观察到状细胞层 (GCL) 和环状视网膜神经纤维层 (cRFNL),胸膜,以及血管密度 (VD) 降低的显著稀薄.
- 在基线没有DKD的患者表现出视网膜和冠状腺厚度的较大下降,以及状血管区域 (FAZ) 的扩大.
- 没有DKD的组在研究结束时表现出更差的血糖控制和功能.
结论:
- 早期和渐进的神经血管损伤发生在T2D患者的视网膜和胆膜中,即使有轻度或没有DR.
- 这种损伤的进展与血糖控制和损伤指标有关.
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