在IgG4相关疾病中的PLA2R阳性膜性病
Yusuke Ushio1, Taro Akihisa2, Kazunori Karasawa2
1Department of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan. ushio.yusuke@twmu.ac.jp.
BMC nephrology
|February 23, 2024
概括
免疫球蛋白G4相关疾病 (IgG4-RD) 可以表现为膜性病,这是一种导致性综合征的脏疾病. 即使具有阳性脂酶A2受体 (PLA2R) 抗体,这种情况也可能是IgG4-RD的次要原因.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 是一种系统性纤维炎症,影响多个器官.
- 脏参与IgG4-RD通常呈现为间歇性炎,但膜性病也可能发生.
- 诊断IgG4-RD需要采用多器官方法,考虑临床,血清学和组织病理学发现.
研究的目的:
- 报告IgG4-RD病例,呈现为带有性综合征的膜性病.
- 为了突显存在脂酶A2受体 (PLA2R) 抗体时的诊断挑战.
- 强调在膜性病的病例中考虑IgG4-RD,无论PLA2R抗体状态如何.
主要方法:
- 一个77岁的男性患有瘤综合征和IgG4相关的肺部疾病的病例报告.
- 对脂酶A2受体 (PLA2R) 抗体进行血清检测.
- 用IgG子类进行免疫光染色的脏活检和对间歇性炎的评估.
主要成果:
- 这位患者呈现了性综合征,血清和脏活检结果对PLA2R抗体呈阳性.
- 脏活检显示膜性脏病,IgG3和IgG4免疫光染色均等.
- 缺少间歇性炎表明IgG4-RD表现为膜性病.
结论:
- 导致性综合征的膜性病可能与IgG4-RD有关.
- 阳性PLA2R抗体并不排除IgG4-RD作为膜性病的潜在原因.
- 临床和病理评估对于区分原发性膜性病与IgG4-RD相关病例至关重要.
更多相关视频
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
2.9K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
434
相关概念视频
Gastritis-II: Pathophysiology
326
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
326
Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
Renal Corpuscle
2.1K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.1K
IP3/DAG Signaling Pathway
12.1K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
12.1K
