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Updated: Jul 2, 2025

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单细胞转录组学在小鼠皮肤过敏模型中确定了从炎症单细胞到亲溶解巨细胞的分化轨迹

Kensuke Miyake1, Junya Ito2, Kazufusa Takahashi2

  • 1Inflammation, Infection and Immunity Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. miyake.mbch@tmd.ac.jp.

Nature communications
|February 23, 2024
PubMed
概括

高Ly6C的经典单细胞在过敏性皮肤炎症中分化为亲溶解的巨细胞. 这一途径依赖于IL-4受体信号传递,通过清除中性粒细胞和过敏原来解决炎症.

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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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