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Updated: Jul 2, 2025

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

在120μT的超极化pyruvate的C MRI

Nicolas Kempf¹, Rainer Körber², Markus Plaumann³

¹High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, 72076, Tübingen, Germany.

Scientific reports

|February 23, 2024

概括

核旋转超极化极大地提高了磁共振灵敏度. 通过可逆交换信号放大 (SABRE) 实现了对酸盐的低场13C代谢成像,展示了其实时应用的潜力.

科学领域:

磁共振成像是一种磁共振成像技术.
超极化技术超极化技术
代谢成像 - 代谢成像

背景情况:

核旋转超极化显著提高了磁共振 (MR) 灵敏度.
这种增强可以实现新的应用,包括实时代谢成像.
以可逆交换 (SABRE) 进行基于基的信号放大是一种关键的超极化方法.

研究的目的:

为了证明13C代谢磁共振成像 (MRI) 在现场使用超极化[1-13C]pyruvate.
为了评估SABRE变体在低磁场 (120μT) 的有效性.
为了展示亚毫米分辨率成像在与地球磁场两倍相比的场所的可行性.

主要方法:

[1-13C]酸盐的超极化利用通过SABRE通过.
应用两种SABRE变体:SABRE在屏蔽中使对齐转移到异质核 (SABRE-SHEATH) 和低辐射产生高特斯拉 (LIGHT-SABRE).
使用超导量子干扰装置 (SQUID) 磁场探测器进行3D成像.

主要成果:

在120μT时,成功实现了50mM [1-13C]pyruvate的13C代谢MRI.
获得了亚毫米分辨率图像,证明了在低电场中的可行性.
通过SABRE的超极化提供了灵敏度的增加,而热极化需要数十亿年的时间.

结论:

低场13C代谢核磁共振 (MRI) 使用副-超极化pyruvate是可行的.
SABRE技术使得在接近地球强度的磁场上进行高灵敏度成像.
这种方法为各种应用中的实时代谢研究开辟了道路.

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Use of a Multi-compartment Dynamic Single Enzyme Phantom for Studies of Hyperpolarized Magnetic Resonance Agents

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