身体脂肪度参数与胰岛素耐药性之间的关系:在日本对代孕标志物的初步研究
Nanae Tanemura1, Tetsuya Kubota2,3,4,5, Naoto Kubota5,6
1National Institutes of Biomedical Innovation, Health and Nutrition, 3-17 Senriokashinmachi, Settsu, Osaka, 566-0002, Japan. n-tanemura@nibiohn.go.jp.
Hormones (Athens, Greece)
|February 23, 2024
概括
甘油三/高密度脂蛋白比率有效地识别了非肥胖男性的胰岛素抵抗,补充了腰围,用于早期肥胖查和预防生活方式疾病.
科学领域:
- 代谢健康 代谢健康
- 预防心血管疾病 预防心血管疾病
- 肥胖问题研究研究
背景情况:
- 糖尿病前期影响人口的很大一部分 (2019年在日本为27.3%).
- 西方化的饮食导致肥胖,脂肪组织功能障碍,胰岛素抵抗和糖尿病.
- 确定可靠的胰岛素耐药性标志物对于早期干预至关重要.
研究的目的:
- 为了评估六个身体脂肪参数与胰岛素抵抗之间的关联.
- 用接收器操作特征 (ROC) 曲线分析来确定这些参数在识别胰岛素耐药性的准确性.
主要方法:
- 这项研究包括248名健康参与者.
- 评估了六个脂肪参数:BMI,腰围 (WC),内脏脂肪指数 (VAI),脂质积累产物指数 (LAP),腰围-三糖指数 (WTI) 和三糖 (TG) /高密度脂蛋白 (HDL) 的比率.
- 使用ROC曲线分析来评估诊断准确度.
主要成果:
- 腰围 (WC) 在肥胖女性和男性中表现出高准确度.
- 甘油三 (TG) /高密度脂蛋白 (HDL) 的比率显示,在非肥胖男性中识别胰岛素抵抗的准确性最高 (AUC:0.780).
结论:
- TG/HDL比率是早期查非肥胖男性的胰岛素抵抗的一个有价值的工具,特别是在例行健康检查期间.
- 将TG/HDL比率与WC整合起来,可以提高对胰岛素耐药性的评估,并有助于预防与生活方式相关的疾病和心血管事件.
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