估计双相情绪障碍,精神分裂症和行为特征对自杀企图的遗传责任的直接影响,使用多变量门德尔随机化方法
Brenda Cabrera-Mendoza1,2, Necla Aydin3,4, Gabriel R Fries5,6
1Department of Psychiatry, Yale School of Medicine, West Haven, CT, 06516, USA. brenda.cabrera-mendoza@yale.edu.
概括
双极性障碍 (BD) 和精神分裂症 (SZ) 的遗传责任增加了自杀企图 (SA) 的风险. 虽然SZ风险独立于精神困扰和冒险,但BD风险是独立的.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 双极性障碍 (BD) 和精神分裂症 (SZ) 与增加自杀企图 (SA) 风险有关.
- 了解遗传倾向和行为因素之间的相互作用对于SA预防至关重要.
研究的目的:
- 调查BD和SZ对SA的遗传责任对BD和SZ的因果关系.
- 检查行为特征,社会经济因素和物质使用障碍在BD/SZ-SA关系中的调解作用.
主要方法:
- 采用两样本的孟德尔随机化 (MR) 分析,使用来自精神病基因组学联盟 (PGC) 和英国生物银行 (UKB) 的大规模基因组范围关联数据.
- 多变量MR被用于评估已识别的风险因素对SA的直接因果影响,控制BD和SZ的遗传责任.
主要成果:
- 对BD (OR=1.24) 和SZ (OR=1.09) 的遗传负债显著增加了SA的几率.
- 精神困扰和冒险行为与SA之间的关联独立于SZ遗传责任.
- BD-SA关联似乎调解了精神痛苦和冒险行为的影响;在考虑SZ遗传责任后,与SA的孤独关联被取消了.
结论:
- 对BD和SZ的遗传风险对SA有很大的贡献.
- 遗传精神病和SA之间的关系是复杂的,受行为和社会经济因素的影响.
- 对于具有精神疾病遗传风险较高的人来说,建议进行全面的心理健康评估,以减轻SA.
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