轻度创伤性脑损伤和职业生涯阶段与特殊行动部队士兵中可见的周血管空间有关
Jacob R Powell1,2, Xiaopeng Zong3, Joshua M Weinstein4
1Human Movement Science, Department of Health Sciences, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Annals of biomedical engineering
|February 24, 2024
概括
具有轻度创伤性脑损伤 (mTBI) 史的军事服务人员表现出周周血管空间 (PVS) 的增加,这表明大脑废物清理可能存在问题. 这一发现表明正在进行的生理变化可能会影响神经健康.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 军事医学 军事医学
背景情况:
- 轻度创伤性脑损伤 (mTBI) 和军事人员的爆炸暴露会损害大脑废物清理,增加神经疾病的风险.
- 周血管空间 (PVS) 对淋巴系统的废物清理功能至关重要,特别是在睡眠期间.
- 在神经退行性疾病和神经创伤动物模型中观察到扩大的PVS.
研究的目的:
- 调查PVS形态,mTBI史和特殊行动部队 (SOF) 士兵的军事职业阶段之间的关联.
- 量化与mTBI和职业风险相关的PVS特征.
主要方法:
- 用T2加权的神经成像来获得223名SOF战斗士的3D全脑体积.
- 在白质中使用深度卷积神经网络进行PVS细分.
- 非参数的曼-惠特尼U测试分析了组之间的PVS数量和体积差异.
主要成果:
- 与没有mTBI史的士兵相比,具有mTBI史的士兵表现出明显更高的PVS数量和体积.
- 在职业生涯中,SOF士兵的PVS数量和体积相对于基线队列相对增加.
- 这些发现在临床上康复的士兵中观察到,表明持续的生理变化.
结论:
- 在SOF战斗士中,mTBI史与增加的PVS负担有关,即使在临床康复后也是如此.
- 升高的PVS可能意味着淋巴系统功能受损,并可能增加神经疾病的风险.
- 需要进一步的研究来探索PVS作为神经生物学结果以及睡眠优化等干预措施的影响.
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