在使用即时释放片剂的患者中,拉莫特里金对奎胺血清度的剂量依赖作用
Kristine Hole1,2, Silje K Lorentsen3,4, Karoline L Nordby3,4
1Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway. kristine.hole@diakonsyk.no.
European journal of clinical pharmacology
|February 24, 2024
概括
高剂量的拉莫特里金显著降低了西的度,但仅在立即释放西的情况下. 建议在处方高剂量的拉莫特里金与奎平IR时进行治疗药物监测.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药物相互作用 药物相互作用
背景情况:
- 据报道,拉莫特里金可以降低奎蒂亚平的血清度.
- 这种相互作用的临床意义,特别是关于lamotrigine剂量和quetiapine配方的临床意义需要进一步调查.
研究的目的:
- 为了确定拉莫特里金剂量或奎平配方是否影响药物相互作用.
- 为了评估高剂量拉莫特里金对奎蒂亚平血清度的影响.
主要方法:
- 对使用拉莫特里金和奎蒂亚平 (病例) 的患者与单独使用奎蒂亚平的对照进行回顾性分析.
- 基因组之间的度与剂量 (C/D) 比率和代谢物与基因 (MPR) 比率的比较.
- 根据奎平配方 (即时释放[IR]与延长释放[XR]) 和拉莫特里金剂量 (高[>200毫克/天]与低[≤200毫克/天]) 的分层.
主要成果:
- 在立即释放 (IR) 配方组中,高剂量拉莫特里金 (每天200毫克以上) 降低了46%的奎蒂亚平C/D比 (P < 0.001).
- 在低剂量拉莫特里金组或与延长释放 (XR) 提氨酸配方中没有观察到显著的相互作用.
- 氨酸代谢物与原始代谢物比率 (MPR) 没有受到lamotrigine剂量或配方的影响.
结论:
- 拉莫特里金和奎蒂亚平之间的相互作用,导致奎蒂亚平水平降低,仅对使用IR配方的高剂量拉莫特里金 (>200毫克/天) 的患者有意义.
- 由于具有显著的变异性,建议在与高剂量拉莫特里金联合处方期间对奎蒂亚平进行治疗药物监测 (TDM).
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