老年人的中风后抑郁症:一个概述
Fabio Giuseppe Masuccio1, Erica Grange1, Rachele Di Giovanni1
1Department of Rehabilitation, C.R.R.F. "Mons. L. Novarese", Loc. Trompone SNC, 13040, Moncrivello, VC, Italy.
Drugs & aging
|February 24, 2024
概括
脑卒中后抑郁症 (PSD) 显著影响老年人,患病率在16.0%至43.9%之间. 有效的诊断和治疗对于改善这一弱势群体的功能结果和生活质量至关重要.
科学领域:
- 老年医学 老年医学
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 脑卒中后抑郁症 (PSD) 是中风后老年人常见且严重的并发症.
- 在这个人口群体中,关于PSD的数据有限,尽管其高度脆弱.
- 由于评估方法和时间的不同,患病率差异很大 (16.043.9%).
研究的目的:
- 审查老年人PSD的患病率,病因,诊断,后果和治疗.
- 突出需要改进PSD在这个群体中的管理策略.
主要方法:
- 关于老年人中风后抑郁症现有文献的叙事综述.
- 分析导致PSD的因素,包括遗传,炎症和结构性大脑变化.
主要成果:
- 老年人的PSD导致功能表现不佳,生活质量降低,死亡风险增加.
- 药理学 (SSRI,SNRIs等等) 的作用. 和非药物治疗方法可用,但未得到充分利用.
- 有限的高质量随机对照试验 (RCT) 专门针对PSD的老年人存在.
结论:
- 治疗PSD对于预防严重并发症和改善患者康复至关重要.
- 需要更多的研究,包括大规模的RCT和标准化诊断工具,以有效管理老年人PSD.
- 在给老年患者开抗抑郁药时,必须仔细考虑并发症和潜在的不良影响.
相关概念视频
Depression: Overview
244
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
244
Cognitive Development During Adulthood
109
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
109
Alzheimer's Disease: Overview
484
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
484
Depressive Disorders: MDD and Dysthymia
136
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
136
Antidepressant Drugs: MAOIs and Other Agents
230
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
230
Post-traumatic Stress Disorder
34
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
34


