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全人口长期研究狼性炎的发病率,功能衰竭和死亡率

Johannes C Nossent^1,2, Helen I Keen^2,3, David B Preen⁴

¹Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

International journal of rheumatic diseases

|February 24, 2024

概括

西澳大利亚的狼性炎 (LN) 发病率在30年内保持稳定,但功能衰竭和死亡率并没有改善,这凸显了需要更好的长期LN治疗的需要.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
类风湿病学类风湿病学
流行病学流行病学

背景情况:

系统性红斑狼 (SLE) 可以导致狼性炎 (LN),这是严重的并发症.
关于LN的流行病学和结果的区域数据有限.
西澳大利亚 (WA) 提供了一个独特的环境来研究LN趋势.

研究的目的:

为了调查西澳大利亚州LN的全州流行病学.
在30年的时间内分析LN的和患者结局.
为了确定LN患者的发病率,死亡率和末期病 (ESRD) 的趋势.

主要方法:

利用了1985-2015年华盛顿州卫生医院发病率数据收集.
包括1480名患有SLE病例的患者,通过血球隆炎和/或血清肌水平升高来定义LN.
分析了使用回归分析的年度发病率 (AIR),死亡率 (MR) 和ESRD率的趋势,与匹配的对照进行了比较.

主要成果:

在25.9%的SLE患者中发生了LN; AIR在0.63/100,000人口中保持稳定.
在LN患者中,ESRD发生在14.1%,明显高于非LN SLE患者和对照组 (p≤0.01).
随着时间的推移,LN患者的ESRD和死亡率随着时间的推移而增加,与对照组相比,死亡的几率比率明显更高.

结论:

在西澳大利亚,LN的发病率在过去的30年里一直保持不变.
在LN患者中,功能衰竭或死亡率没有显著改善.
对于狼性炎,迫切需要加强长期治疗策略.

关键词:

最终阶段的脏疾病.流行病学流行病学狼性炎是一种神经炎症.死亡率死亡率系统性红血性狼 (Systemic Lupus Erythematosus) 是一种全身性狼.

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