在与代谢功能障碍相关的脂肪性肝病患者中,高风险冠状动脉斑块的患病率增加:元分析
Ovidio De Filippo1,2, Gianluca Di Pietro1,3, Marco Nebiolo2
1Division of Cardiology, Cardiovascular and Thoracic Department, Città della Salute e della Scienza Hospital, Turin, Italy.
European journal of clinical investigation
|February 24, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者出现关键冠状动脉狭窄和高风险冠状动脉斑块的风险较高. 计算机断层扫描冠状动脉扫描 (CTCA) 在MASLD个体中揭示了这些增加的风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 放射学 放射学是一门学科.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是冠状动脉疾病的重要危险因素.
- 计算机断层扫描冠状动脉扫描 (CTCA) 是评估冠状动脉斑块范围和特征的关键成像方式.
研究的目的:
- 调查MASLD患者冠状动脉斑块的患病率和特征.
- 为了比较MASLD患者的冠状动脉斑块特征与对照组.
主要方法:
- 在PubMed,Scopus和谷歌学者中进行了系统的文献搜索.
- 包括的研究是随机对照试验和调整的观察性研究,比较MASLD患者与对照.
- 终点包括冠状动脉狭窄,冠状动脉 (CAC) 评分和高风险斑块特征 (例如,低衰减,斑点化,积极重塑).
主要成果:
- 在MASLD患者中,临界冠状动脉狭窄的患病率较高 (OR 1.54).
- 在MASLD患者中观察到冠状动脉 (CAC) 评分的增加 (OR 1.35对于CAC 0-100,OR 2.26对于CAC>100).
- MASLD与高风险冠状动脉斑块 (OR 2.13) 的风险增加有关,特别是积极的重塑和斑点化.
结论:
- 患有MASLD的患者面临患有关键冠状动脉狭窄症的风险较高.
- CTCA成像表明,MASLD与具有高风险特征的冠状动脉斑块有关,这表明心血管风险概况较高.
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