狗前列腺癌的临床病理学表征
Demitria M Vasilatis1,2, Paramita M Ghosh1,2,3
1Department of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USA.
Animals : an open access journal from MDPI
|February 24, 2024
概括
临床病理学数据可以帮助区分狗前列腺癌类型. 低albuminemia表明前列腺腺癌,而Melamed-Wolinska体和亡表明过渡细胞癌,有助于进行前死亡诊断.
科学领域:
- 兽医瘤学 兽医瘤学
- 狗的病理学 狗的病理学
- 比较性瘤学研究
背景情况:
- 准确区分犬前列腺癌 (PCa) 类型对于治疗至关重要,但往往缺乏足够的临床病理学数据.
- 初级前列腺腺癌 (PRAD) 和初级前列腺过渡细胞癌 (P-TCC) 是不同的实体,需要特定的诊断方法.
研究的目的:
- 评估临床病理学数据,以区分狗狗的PRAD和P-TCC.
- 评估红细胞分布宽度与白蛋白比率 (RAR) 在区分PRAD和P-TCC的诊断实用性.
- 为了比较实验室数据和雄激素受体阳性 (AR+) 和阴性 (AR-) PRAD瘤之间的存活率.
主要方法:
- 对56只患有PRAD的狗和74只患有P-TCC的狗的人口统计,临床病理学,细胞学和生存数据 (1992-2022) 的回顾性分析.
- 评估红细胞分布宽度 (RDW) 和白蛋白水平,以计算诊断实用性的RAR.
- 在PRAD瘤中对雄激素受体 (AR) 表达的组织化学染色.
主要成果:
- 增加的RDW和减少的白蛋白与PRAD显著相关 (p <0.05).
- 细胞学上的梅拉米德-沃林斯卡体 (MWB) 和与P-TCC显著相关 (p <0.05).
- 在区分PCa瘤 (AUC = 0.7; p < 0.05) 中,RAR显示了可接受的诊断效用. 低蛋白血症与PRAD中存活率降低相关. 在PRAD中,AR状态没有影响临床病理学数据或生存率.
结论:
- 低albuminemia是PRAD和狗的生存率较低的潜在指标.
- 对MWB和亡的细胞学发现可能有助于在死前确定P-TCC.
- 临床病理学数据,包括RAR,可以帮助区分狗前列腺癌类型,指导治疗决策.
相关概念视频
01:20Disorders of the Male Reproductive System
416
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
416
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K