探索羊MAST4基因变异及其与子大小的关联
Nazar Akhmet1, Leijing Zhu1, Jiajun Song1
1Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Animals : an open access journal from MDPI
|February 24, 2024
概括
在MAST4基因的遗传变异影响绵羊子大小. 这些发现支持使用MAST4基因多态性用于标记器辅助选择,以提高绵羊的繁殖率和繁殖效率.
科学领域:
- 动物遗传学动物遗传学
- 畜牧养殖 畜牧养殖 畜牧养殖
- 基因组学就是基因组学.
背景情况:
- 羊的生产力是养羊的经济效率的关键.
- 全基因组协会研究 (GWAS) 确定了MAST4基因在澳大利亚白羊 (AUW) 的繁殖特征中的潜在作用.
研究的目的:
- 为了研究MAST4基因多态的分布和关联,跨越不同的绵羊品种.
- 评估MAST4基因变异在改善绵羊繁殖能力的标记辅助选择中的有用性.
主要方法:
- 全球26个品种1507只绵羊的全基因组测序 (WGS).
- 在566只澳大利亚白羊中,聚合酶链反应 (PCR) 基因定型MAST4基因多态.
- 在AUW绵羊中,确定了多态和子大小之间的关联分析.
主要成果:
- 在MAST4基因中发现了三种多态 (P3-ins-29 bp,P6-del-21 bp,P5-del-24 bp).
- 在26个品种中,多态度的频率各不相同,在中国的肉类/双重用途品种中,P3-ins-29 bp更为常见.
- 所有确定的InDels (插入/删除) 都与澳大利亚白羊的子大小有显著的关联 (p < 0.05).
结论:
- 在MAST4基因中发现的InDels在各种羊品种中普遍存在.
- 这些MAST4基因多态性与澳大利亚白羊的子大小有关.
- MAST4基因变异显示了标记器辅助选择的潜力,以提高绵羊的繁殖率.
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