德尔-1通过抑制炎症和亡,对COPD发展起着保护作用
Nakwon Kwak1,2, Kyoung-Hee Lee1, Jisu Woo1
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
International journal of molecular sciences
|February 24, 2024
概括
在慢性阻塞性肺病 (COPD) 肺部,发育性内皮位-1 (Del-1) 降低. 通过Nrf2激活Del-1,通过减少炎症和亡,提供对COPD的保护.
科学领域:
- 肺部医学 肺部医学
- 炎症研究 炎症研究
- 分子生物学分子生物学
背景情况:
- 中性质炎症是慢性阻塞性肺病 (COPD) 的标志.
- 已知发育性内皮位-1 (Del-1) 调节中性粒细胞粘附和炎症.
- 德尔-1在COPD病变发生过程中的具体作用尚不清楚.
研究的目的:
- 研究Del-1在COPD病变发生过程中的作用和机制.
- 在COPD模型中确定Del-1对炎症和亡途径的影响.
主要方法:
- 在人类COPD肺组织中分析Del-1蛋白表达.
- 在体外研究中,使用暴露于香烟烟雾提取物 (CSE) 的上皮细胞和巨细胞.
- 操纵Del-1表达 (过度表达和淘汰),评估炎症标志物和亡.
- 核因素红色素2相关因子2 (Nrf2) 和其激活剂的作用的研究.
主要成果:
- 在COPD患者的肺部,特别是上皮细胞和膜巨细胞中,Del-1表达减少.
- 德尔-1过度表达抑制了CSE治疗细胞中的IL-8释放和细胞亡,而Knockdown则加剧了这些影响.
- 德尔-1通过调节NF-κB p65酸化和乙化来抑制巨细胞中炎症性细胞因子的释放.
- Nrf2激活剂 (quercetin,resveratrol,sulforaphane) 在两种细胞类型中都增加了Del-1表达.
结论:
- 德尔-1对COPD的病原发生有保护作用.
- 德尔-1具有抗炎和抗亡功能,部分通过Nrf2通路进行介导.
- 针对Del-1或激活Nrf2可能是COPD的治疗策略.
相关概念视频
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
COPD: Management Using Bronchodilators and Corticosteroids
206
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
206
COPD: Pathogenesis and Clinical Features
273
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
273
Drugs Used in Lower Respiratory Disorders: Overview
442
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
442
The Extrinsic Apoptotic Pathway
6.4K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.4K
Inflammatory Response
2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K


