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Updated: Jul 2, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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大多数单一性疾病是由改变蛋白质折叠自由能量的突变引起的

Preeti Pandey1, Emil Alexov1

  • 1Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA.

International journal of molecular sciences
|February 24, 2024
PubMed
概括

一个更新的单一性疾病数据库 (MOGEDO) 显示,大多数病原性突变会降低蛋白质的稳定性. 这一发现支持在微小分子的选中稳定突变蛋白质,有助于针对罕见遗传疾病的向药物开发.

关键词:
折叠的自由能量 折叠的自由能量单源性疾病 单源性疾病突变是一种突变.病原性 病原性 病原性蛋白质的稳定性 蛋白质的稳定性

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