在肝硬化中肠道微生物群和内皮功能障碍的生物标志物
Irina Efremova1, Roman Maslennikov1,2,3, Elena Poluektova1,2
1Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya Str. 1-1, 119435 Moscow, Russia.
International journal of molecular sciences
|February 24, 2024
概括
内皮功能障碍生物标志物如酸盐和ADMA在肝硬化中升高,与疾病严重程度,细菌转移和改变的肠道微生物群有关. 这些发现突出了肝病管理中的潜在诊断和治疗目标.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 微生物学 微生物学
- 心血管生理学心血管生理学
背景情况:
- 肝硬化与内皮功能障碍,细菌转位和肠道失调有关.
- 内皮和肠道屏障功能障碍的生物标志物需要在肝病中进一步调查.
研究的目的:
- 调查内皮功能障碍生物标志物,肝硬化严重程度,细菌转移和肠道微生物群组成之间的关联.
主要方法:
- 使用16S rRNA基因测序进行便微生物组分析.
- 血生物标志物的测量:亚酸盐,大内甲蛋白-1,不对称的二甲基亚氨酸 (ADMA),普雷塞普辛和克劳丁.
- 声心图用于评估血液动力学参数.
主要成果:
- 与对照组相比,肝硬化患者的普雷塞普辛,克劳丁3,酸盐和ADMA水平较高.
- 升高的亚酸盐与增加的普雷塞普辛,克劳丁3相关,血液动力学变化,低albuminemia,,肝脏脑病,以及特定的细菌种群 (Proteobacteria,Erysipelatoclostridium).
- 升高的ADMA与更高的Child-Pugh评分,较低的,低蛋白血,,肝脏脑病和改变的肠道微生物群 (Erysipelotrichia) 相关.
结论:
- 内皮功能障碍生物标志物在肝硬化中显著变化,与疾病严重程度和肠道功能障碍相关.
- 这些生物标志物可以作为细菌转移和肠道屏障功能障碍在肝病的指标.
- 对这些关联的进一步研究可以为肝硬化治疗的新治疗策略提供信息.
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