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基基-贝塔环氧德克斯林屏障可以预防呼吸道病毒感染:临床前研究

Angela Lu¹, Brandon Ebright¹, Aditya Naik¹

¹Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.

International journal of molecular sciences

|February 24, 2024

概括

基甲-循环德克斯 (HPBCD) 鼻腔配方显示出作为预防性治疗病毒感染的前景. 研究表明,HPBCD可以降低病毒载量和炎症,作为对抗SARS-CoV-2等病原体的屏障.

科学领域:

病毒学病毒学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

新兴和突变的病毒,包括SARS-CoV-2,对全球健康构成重大威胁.
ангиотензин转化酶2 (ACE2) 的表达在鼻腔呼吸道中是最高的,这表明它是SARS-CoV-2的主要入口途径.
针对鼻腔呼吸道的预防疗法可以减少病毒传播和随后的肺部并发症.

研究的目的:

评估基于环极素的配方的安全性和抗病毒疗效.
评估基甲基β-环氧化 (HPBCD) 和基甲基-环氧化 (HPGCD) 对它们阻断病毒进入的潜力.
研究HPBCD作为一种潜在的对传染性病原体的不可知障碍物.

主要方法:

在实验室中使用SARS-CoV-2伪型评估HPBCD和HPGCD.
在体内使用K18-hACE2小鼠模型感染SARS-CoV-2Delta变种的实体疗效研究.
进行体外抗病毒检测,以检测对象病毒,小鼠肝炎病毒 (MHV) 和甲型流感病毒 (H1N1).

主要成果:

基于HPBCD的配方对SARS-CoV-2伪型表现出显著的抗病毒作用.
用HPBCD进行鼻内预治疗减少了感染小鼠肺部的病毒载量和炎症信号.
在HPBCD中,HPBCD对多种病毒表现出有效性,包括SARS-CoV-2变种,MHV和H1N1.

结论:

基于HPBCD的鼻腔配方在减少病毒载量和炎症方面是安全有效的.
HPBCD作为一种不可知障碍物,为一系列传染性呼吸道病毒提供潜在的预防疗法.
这种方法针对病毒进入的主要地点,为传染病控制提供了一种新的策略.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.循环德克斯特林 (Cyclodextrin) 是一种循环德克斯特林.这是一种炎症炎症炎症炎症.病毒复制病毒复制

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