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Updated: Jul 2, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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GATOR1 突变 损害 PI3 激酶依赖生长因子 信号 调节 mTORC1 的调节

Maéline Muller1, Jasmine Bélanger1, Imane Hadj-Aissa1

  • 1Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Quebec City, QC G1J 2G3, Canada.

International journal of molecular sciences
|February 24, 2024
PubMed
概括

与相关的NPRL2突变破坏了GATOR1复合体,导致无法控制的mTORC1信号传递. 这损害了细胞对营养和生长因子信号的反应,为病的发病过程提供了洞察力.

关键词:
在 GATOR1 的位置上.这是NPRL2的NPRL2.在NPRL3中,NPRL3中,NPRL3中,NPRL3中这就是PI3激酶.氨基酸是氨基酸中的一种.是一种.增长因子信号传递.在 mTORC1 的情况下,mTORC1 是代谢过程中的代谢.转录 转录 是一种转录.翻译翻译翻译翻译翻译翻译

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