维生素D3和植物化学品对其抗衰老作用的潜在用途
Kazuki Santa1, Yoshio Kumazawa2,3, Kenji Watanabe4,5
1Department of Biotechnology, Tokyo College of Biotechnology, Ota-ku, Tokyo 114-0032, Japan.
International journal of molecular sciences
|February 24, 2024
概括
维生素D3和植物衍生的植物化学物质共同作用,减少炎症并支持健康的衰老. 补充是保持肠道健康和预防与年龄有关的疾病的关键.
科学领域:
- 免疫学和营养科学 免疫学和营养科学
- 分子生物学分子生物学
- 老年学是指老年学的学科.
背景情况:
- 在皮肤中合成的维生素D3对于骨健康至关重要,并因其免疫调节特性而越来越受欢迎.
- 植物化学物质,如黄类植物化合物,通过调节促炎细胞因子,如瘤死因子-α (TNF-α) 等,具有抗炎作用.
- 慢性炎症是由持续的TNF-α生产驱动的,与许多疾病和衰老过程有关.
研究的目的:
- 审查维生素D3和植物化学物质在抑制炎症反应中的协同作用.
- 探索它们在平衡免疫系统和促进抗衰老作用中的作用.
- 突出它们在维持肠道微生物群和预防与年龄有关的疾病方面的重要性.
主要方法:
- 对维生素D3,植物化学物质,炎症和衰老研究的文献综述.
- 分析涉及维生素D受体 (VDR) 和细胞因子调节的机制.
- 检查饮食,肠道微生物群和健康范围之间的相互作用.
主要成果:
- 维生素D3和植物化学物质合作抑制炎症并平衡免疫反应.
- 联合补充显示了协同作用的抗衰老效应,可能是通过与衰老相关基因的相互作用.
- 通过饮食维持健康的肠道微生物群,包括维生素D3和植物化学物质,对于预防炎症诱导的衰老至关重要.
结论:
- 维生素D3和植物化学物质为对抗慢性炎症和促进健康衰老提供了一个有希望的策略.
- 它们的协同作用支持免疫平衡,并可能抵消与年龄相关的基因表达.
- 饮食摄入量和补充剂对于利用这些益处和促进长寿和预防性健康 (ME-BYO) 至关重要.
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
01:25Role of Vitamins in Maintaining Bone Health
3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K
01:37Mitochondria
12.6K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
12.6K
01:26Aging
51
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
51
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:30Vitamins
721
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
721