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丸生殖细胞瘤中的微RNA:瘤挑战

Nuphat Yodkhunnatham¹, Kshitij Pandit¹, Dhruv Puri¹

¹Department of Urology, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.

International journal of molecular sciences

|February 24, 2024

概括

微RNAs (miRNAs) 在诊断丸生殖细胞瘤 (TGCTs) 方面表现有前途. 循环的miR-371a-3p有助于TGCT检测和监测,而其他miRNA有助于区分瘤类型,尽管仍然需要一个可靠的瘤标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

丸生殖细胞瘤 (TGCTs) 在年轻男性中很常见,需要准确的诊断和预后.
微RNAs (miRNAs) 正在成为TGCTs潜在的非侵入性生物标志物.
在化疗后区分残留质量 (瘤,可活性瘤,缩) 是临床上至关重要的.

研究的目的:

审查用于TGCT诊断和预后的miRNA生物标志物的进展.
突出循环miRNAs在非侵入性TGCT检测和监测方面的潜力.
讨论识别可靠生物标志物的挑战,特别是对瘤.

主要方法:

对TGCTs中miRNA生物标记物的最新文献的综述.
专注于TGCTs中的循环微RNA-371a-3p (miR-371a-3p) 表达.
研究其他miRNAs (例如,miR-375家族) 以区分TGCT亚型.

主要成果:

循环中的miR-371a-3p是未分化TGCT的有希望的生物标志物,可在血清和血中检测到.
miR-375家族miRNAs显示出区分瘤,可活性瘤和亡的潜力.
确定的非侵入性生物标志物用于瘤检测仍然难以捉摸.

结论:

miRNA生物标志物,特别是miR-371a-3p,为改善TGCT诊断,监测和治疗反应监测提供了显著的潜力.
结合miR-371和miR-375可能会提高残余质量的诊断精度.
进一步临床验证和miRNA生物标记物的标准化对于在TGCT管理中广泛实施至关重要.

关键词:

这是一个微型RNA.丸癌症丸癌症是什么丸的生殖细胞瘤

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...