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Updated: Jul 2, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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在BF.5和BF.7亚系中发现的SARS-CoV-2ORF7a突变影响其功能

Uddhav Timilsina1, Emily B Ivey1, Sean Duffy1

  • 1Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.

International journal of molecular sciences
|February 24, 2024
PubMed
概括

在SARS-CoV-2 Omicron亚变体中的ORF7a:H47Y突变损害了I型干扰素反应的病毒对抗性,并降低了MHC-I细胞表面水平,可能改变病毒病原性.

关键词:
主要的组织相容性复杂I.突变是一种突变.打开阅读框架7a (ORF7a) 的阅读框.严重急性呼吸系统综合征新冠病毒2第一种类型的干扰素反应反应.

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