HERVs:在疾病和人类免疫缺陷病毒感染中的表达控制机制和相互作用
Federica Mantovani1, Konstantina Kitsou1, Gkikas Magiorkinis1
1Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Genes
|February 24, 2024
概括
人体内源逆转录病毒 (HERVs),古代感染的遗留物,占人类DNA的8%,由表观遗传机制调节. 本综述探讨了HERV沉默,它们在疾病中的作用以及与HIV的相互作用.
科学领域:
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 病毒学 病毒学
背景情况:
- 人体内源逆转录病毒 (HERVs) 是人类基因组中集成的古老逆转录病毒序列,约占人类DNA的8%.
- 虽然在很大程度上被禁用,但HERVs可以被选择为宿主利益,并且它们的表达受到多种机制的严格调节.
研究的目的:
- 审查参与HERV基因沉默的主要途径.
- 检查HERVs在人类疾病中的作用.
- 要突出HERVs和人类免疫缺陷病毒 (HIV) 感染之间的相互作用.
主要方法:
- 本综述综合了关于HERV生物学,表观遗传调节和疾病关联的现有文献.
- 它特别关注总结HERV沉默机制及其对病理学的影响.
- 该审查还审查了HERVs和HIV之间的记录互动.
主要成果:
- 表观遗传修饰,包括DNA甲基化,基因组修饰和转录后控制,对于维持HERV表达平衡至关重要.
- HERV表达的失调与各种人类疾病有关.
- 讨论了HIV感染期间HERVs的特定相互作用和潜在影响.
结论:
- HERV表达是由表观遗传和后转录机制的复杂网络复杂地控制的.
- 了解 HERV 调节及其病理作用对于疾病研究至关重要.
- 对HERV-HIV相互作用的进一步调查可能会提供对病毒病原和宿主反应的见解.
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