由从母乳养婴儿中分离出来的肠杆菌产生的肠杆菌:抗性潜力
José María Landete1, Raquel Montiel1, Eva Rodríguez-Mínguez1
1Department of Food Technology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, INIA-CSIC, Carretera de La Coruña Km 7, 28040 Madrid, Spain.
Children (Basel, Switzerland)
|February 24, 2024
概括
婴儿的肠球菌会产生抑制Listeria monocytogenes的肠球蛋白. 这些素显示出治疗抗生素耐药性感染和开发益生菌的潜力.
科学领域:
- 微生物学 微生物学
- 食品科学 食品科学 食品科学
- 细菌学 细菌学是一门学科.
背景情况:
- 菌可以合成菌素,这种细菌素对Listeria monocytogenes等食物传播病原体有效.
- 婴儿肠道微生物群是具有抗菌性能的有益细菌的来源.
研究的目的:
- 识别和分析婴儿衍生的Enterococcus中的素基因表达.
- 评估这些素对Listeria monocytogenes和益生菌的抑制作用.
主要方法:
- 从母乳养的婴儿中分离和识别菌株.
- 检测和分析素基因的产生 (素A,B,P,AS-48).
- 对Listeria monocytogenes菌株抗生素和菌素的抗菌感应性测试.
主要成果:
- 菌产生了甲素A,B和P;菌产生了素AS-48.
- 氨酸AS-48独立抑制了Listeria monocytogenes;氨酸A+B或B+P显示出协同抑制作用.
- 素表达与Listeria monocytogenes抑制能力相关;益生菌在很大程度上不受影响,除了Bifidobacterium longum BB536.
结论:
- 婴儿衍生的Enterococcus中的内素表现出显著的抗菌活性.
- 生产菌素的Enterococcus菌株显示出作为益生菌和开发抗生素替代品抗耐药病原体的潜力.
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