青少年时期的父母社会隔离改变了小鼠雄性后代的肠道微生物组

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Carlotta Siddi¹, Sofia Cosentino², Elena Tamburini³

¹Department of Life and Environmental Sciences, Section of Neuroscience and Anthropology, University of Cagliari, Monserrato, 09042 Cagliari, Italy.

|February 24, 2024

概括

在老鼠中,父母的压力会改变后代的肠道细菌,增加皮质水平. 这些变化表明环境因素可以影响后代的健康和疾病风险.

科学领域:

微生物学微生物学
神经内分泌学神经内分泌学
环境健康环境健康

背景情况:

父母的压力导致男性后代的行为,内分泌功能和生物化学发生显著变化.
这些效应以前在男性斯普拉格-道利大鼠中观察到,这些大鼠在青春期遭受了社会隔离压力.

研究的目的:

研究父母压力对男性后代肠道微生物群组成的影响.
检查肠道微生物变化,压力荷尔蒙和暴露于父母压力的后代的炎症标志物之间的关系.

主要方法:

利用16S rRNA基因的下一代测序 (NGS) 来分析肠道细菌群落.
在社会隔离父母 (ISO-O) 和分组住宿对照 (GH-O) 的男性后代之间的肠道微生物组成比较.
测量了互白素-1-β,瘤亡因子-α和皮质的血水平.

主要成果:

在ISO-O大鼠中观察到肠道微生物组合的显著变化,这些变化发生在主要族群中的家族和顺序层面.
在ISO-O中发现了Limosilactobacillus reuteri的显著减少和Ligilactobacillus murinus的增加.
在ISO-O中检测到血皮质水平升高,而促炎性细胞因子水平保持不变.

结论:

在发育过程中父母的压力显著重塑了男性后代的肠道微生物群.
在ISO-O中增加的皮质水平表明与微生物失生症相关的持续性应激反应.
这些发现突出了父母环境条件通过表观遗传或微生物途径影响后代健康和疾病易感性的潜力.

关键词:

皮质类皮质类固醇.细胞因子细胞因子我们的肠道微生物组.雄性大鼠的后代是它们的后代.在怀孕前的压力.社会隔离,社会隔离.

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