相关实验视频

Updated: Jul 2, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

免疫治疗的LILRB4检查点:结构,机制和疾病点

Zhiqing Xiang¹, Xiangli Yin¹, Leiyan Wei¹

¹Department of Immunology, Xiangya School of Medicine, Central South University, Changsha 410078, China.

|February 24, 2024

概括

白细胞免疫球蛋白样受体B4 (LILRB4) 通过抑制免疫反应来调节免疫耐受性. 准LILRB4为自身免疫性疾病,移植耐受性和癌症提供了潜在的治疗方法.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

LILRB4是一种髓质抑制受体,对免疫耐受性至关重要.
它通过ITIM传输抑制信号,调节免疫反应.
LILRB4被认为是一个关键的免疫检查点分子.

研究的目的:

提供LILRB4.4的全面审查.
阐明LILRB4.4的结构,表达,连接体和耐受性函数.
突出LILRB4在疾病中的作用及其治疗潜力.

主要方法:

关于LILRB4结构,表达和功能的文献综述.
对LILRB4在免疫耐受性和疾病发病过程中的参与进行分析.
探索LILRB4的治疗影响.

主要成果:

LILRB4诱导效应T细胞功能障碍,并促进T抑制细胞的分化.
它在自身免疫性疾病和移植耐受性中起着重要作用.
LILRB4调节会影响免疫反应,这与癌症治疗有关.

结论:

LILRB4是免疫耐受性的关键调节者,具有多种功能.
它的操纵是一个有前途的免疫治疗策略.
LILRB4具有预防,治疗和诊断疾病的潜力.

关键词:

这就是LILRB4的原因.检查站检查站检查站检查站检查站免疫耐受性免疫耐受性细胞耐受性的细胞耐受性.

更多相关视频

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.