精油成分对类固醇性细胞染色体P450活性的影响
Katyayani Sharma1,2,3, Angelo Lanzilotto1,2, Jibira Yakubu1,2,3
1Division of Endocrinology, Diabetology and Metabolism, Department of Pediatrics, University Children's Hospital, Inselspital, University of Bern, 3010 Bern, Switzerland.
Biomolecules
|February 24, 2024
概括
精油可以通过抑制CYP17A1和CYP19A1.1等关键酶来破坏激素平衡. 一些化合物显示出治疗前列腺癌 (PCa) 和PCOS等高雄激素性疾病的潜力.
科学领域:
- 内分泌学 在内分泌学.
- 生物化学 生物化学
- 计算化学计算化学
背景情况:
- 内分泌干扰化学物质 (EDC) 可以通过改变类固醇代谢来影响前列腺癌 (PCa) 的发展.
- EDCs可能会抑制类固醇酶 (CYP17A1,CYP19A1),影响雄激素和雌激素的产生.
- 香衣草和茶树油等精油 (EO) 被怀疑是与性别类固醇失衡相关的EDC.
研究的目的:
- 研究EO成分对CYP17A1和CYP19A1活性的影响.
- 使用计算对接来预测EO与类固醇酶的结合亲和力.
- 评估EO作为治疗高雄激素障碍的治疗剂的潜力.
主要方法:
- 对各种EO成分对CYP17A1和CYP19A1的影响进行查1.
- 计算对接用于预测绑定相互作用.
- 使用放射性标记基板和液体染色学-高分辨率质谱的功能性测试.
- 在LNCaP细胞中进行细胞活力测试.
主要成果:
- 一些经过测试的EO化合物与CYP17A1和CYP19A1的活性位点附近结合.
- (+) - 塞德罗尔对CYP17A1和CYP19A1.1表现出最强的结合亲和力.
- 欧卡利普托,Dihydro-β-Ionone和 (-) -α-pinene抑制了20-40%的脱水氨的产生;其他化合物受到CYP19A1.1.的影响.
结论:
- 长时间接触某些EO可能导致类固醇失衡.
- EO对雄激素生产的抑制作用表明了潜在的治疗应用.
- 的成分可能会激发针对PCa和PCOS等高雄性疾病的新型治疗方法的设计.
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