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相关概念视频

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
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Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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相关实验视频

Updated: Jul 2, 2025

MicroRNA In situ Hybridization for Formalin Fixed Kidney Tissues
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结石中的非编码RNAs

Guilin Wang1, Jun Mi1, Jiangtao Bai1

  • 1Department of Urology, Institute of Urology, Gansu Nephro-Urological Clinical Center, Key Laboratory of Urological Diseases in Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China.

Biomolecules
|February 24, 2024
PubMed
概括

非编码RNA,如microRNAs (miRNAs) 和长非编码RNAs (lncRNAs),越来越多地认识到它们在结石 (结石) 发育和损伤中的作用. 对这些分子的进一步研究可能会提供新的诊断和治疗策略.

关键词:
生物标志物 生物标志物造成脏损伤的人.结石 结石是指结石的发生.没有编码的RNAs.治疗应用 治疗应用

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科学领域:

  • 生物化学 生物化学
  • 分子生物学分子生物学
  • 腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

  • 结石 (结石) 是一种普遍的疾病,具有显著的发病率和高复发率.
  • 造成结石形成和相关损伤的精确机制尚未完全理解.
  • 非编码RNAs,包括microRNAs (miRNAs) 和长非编码RNAs (lncRNAs),正在成为结石发病的关键调节者.

研究的目的:

  • 在结石病的背景下,审查目前对非编码RNA的理解.
  • 探索miRNAs和lncRNAs作为结石诊断生物标志物的潜力.
  • 讨论非编码RNAs,如小干扰RNAs (siRNAs) 在结石管理中的治疗含义.

主要方法:

  • 关于在甲病中研究非编码RNA的研究的文献综述.
  • 分析miRNA和lncRNA参与结石形成的关键病理过程.
  • 对竞争的内源RNA (ceRNA) 网络的检查,涉及 lncRNA 和 miRNA.

主要成果:

  • 许多特定的miRNA涉及到结石病,影响和氧酸盐代谢,氧化应激,细胞结晶粘附,自,亡和巨两极分化.
  • 新出现的证据支持使用miRNAs作为结石的潜在诊断生物标志物.
  • LncRNAs作为ceRNAs起作用,调节mRNA表达并影响结石相关的生理机制.

结论:

  • 非编码RNA在结石病变和与结石相关的损伤的发病过程中发挥着重要作用.
  • 对miRNAs和lncRNAs的进一步研究为结石的新型诊断和治疗策略提供了有希望的途径.
  • siRNAs代表了预防和治疗结石的潜在未来治疗方法.