查诺梅莱斯辛尼西斯提取物通过抑制IL-33/ST2轴和调节上皮细胞功能障碍来改善卵素诱导的过敏性鼻炎
Juan Jin1, Yan Jing Fan1, Thi Van Nguyen1
1Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.
Foods (Basel, Switzerland)
|February 24, 2024
概括
柴诺梅莱斯辛尼西斯提取物 (CSE) 通过调节炎症反应和改善鼻腔组织健康,有效地减少了小鼠过敏性鼻炎 (AR) 症状. 这表明CSE.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 传统医学的传统医学.
背景情况:
- 传统上使用Chaenomeles sinensis治疗炎症,高血压和突变发生.
- 关于Chaenomeles sinensis提取物 (CSE) 对过敏性鼻炎 (AR) 的影响的研究有限.
研究的目的:
- 研究CSE在AR上的治疗潜力.
- 在卵胺诱导的AR小鼠模型中阐明CSE的潜在机制.
主要方法:
- 卵胺 (OVA) 诱导的AR小鼠模型.
- 评估OVA特异性免疫球蛋白 (IgE,IgG2a),鼻腔症状,细胞因子 (Th1/Th2),炎症细胞透和鼻腔组织病理学.
- 评价上皮质透性和E-cadherin的表达.
- 对IL-33/ST2信号通路的分析.
主要成果:
- CSE抑制了OVA特异性IgE,改善了Th2细胞因子的产生,同时增加了Th1细胞因子.
- 通过高调节E-cadherin,CSE治疗抑制了IL-33/ST2信号传递,并逆转了OVA诱导的上皮屏障功能障碍.
- 施用CSE减少了炎症细胞的透,改善了鼻腔和肺部组织病理学.
结论:
- CSE在控制过敏反应和抑制AR中的呼吸道炎症方面表现出显著的治疗疗效.
- CSE具有作为治疗过敏性鼻炎和相关的呼吸道疾病的潜力.
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