性别对XOR活动和相关病理的影响:叙述性审查
Andrea Bolognesi1, Massimo Bortolotti1, Maria Giulia Battelli1
1Department of Medical and Surgical Sciences-DIMEC, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy.
Antioxidants (Basel, Switzerland)
|February 24, 2024
概括
精氨酸代谢中的性别差异影响健康. 在男性中,尿酸和丁氧化还原酶 (XOR) 活性较高与疾病有关,这表明需要针对性别的治疗来获得更好的健康结果.
科学领域:
- 生物化学 生物化学
- 医学科学 医学科学 医学科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 性别特定的生理差异存在,影响疾病风险和治疗.
- purin 代谢,涉及尿酸和山丁氧化还原酶 (XOR),显示了显著的性别差异.
- 尿酸和XOR水平升高与各种病理有关,包括痛风,高血压和代谢障碍.
研究的目的:
- 审查纯氨酸代谢中与性别相关的差异.
- 分析血清尿酸/XOR水平与相关病理之间的关联.
- 探索以性别为导向的药理干预的机会.
主要方法:
- 文献综述,重点关注纯素代谢中的性别差异.
- 对将尿酸和XOR水平与疾病患病率联系起来的研究分析.
- 根据性别特异性代谢特征量身定制的药理学方法的研究.
主要成果:
- 尿酸和XOR活性的生理血清水平在男性中高于女性.
- 这些男性的高水平与痛风,高血压,心血管,脏和代谢疾病的风险增加有关.
- purin 代谢的病理后果存在显著的基于性别的差异.
结论:
- 承认性别对于精确和公平的医学至关重要.
- 尿酸和XOR代谢的性别特异性变化需要量身定制的治疗策略.
- 基于性别的药理疗法有望更有效地管理相关疾病.
相关概念视频
Socioemotional Experience and Gender Development
30
Social-emotional experiences and cultural influences play significant roles in shaping gender development. During middle childhood, from ages 6 to 11, peer groups become dominant in reinforcing gender norms. Children in this age group often align with same-gender peer groups, which actively encourage behaviors that conform to traditional gender roles. For instance, boys may be discouraged from engaging in activities perceived as feminine, reinforcing culturally dictated norms about masculinity...
30
Psychosexual Stages of Personality: Genital
639
The genital stage is the final phase of Sigmund Freud's theory of psychosexual development, beginning at puberty, around age 12. During this stage, sexual energy shifts from self-focused interests to external individuals, marking the development of mature adult sexuality. Freud saw this phase as a time of sexual reawakening, with desires directed toward others outside the family. A healthy transition into this stage, according to Freud, signifies the emergence of two key aspects of adult...
639
Disorders of the Male Reproductive System
416
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
416
Disorders of the Female Reproductive System
361
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
361
Sex-linked Disorders
102.1K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.1K
X-linked Traits
54.9K
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
54.9K


