骨髓系衍生抑制细胞在肝脏疾病中的作用
Chunye Zhang1, Yuxiang Sui2, Shuai Liu3
1Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65212, USA.
Biomedicines
|February 24, 2024
概括
骨髓原抑制细胞 (MDSCs) 通过调节免疫反应,显著影响肝病的进展. 针对这些细胞为各种肝脏疾病提供了潜在的治疗策略,尽管在精确识别方面存在挑战.
科学领域:
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
- 细胞生物学 细胞生物学
背景情况:
- 肝病导致全球显著的死亡率,免疫细胞在其病变发生过程中起着至关重要的作用.
- 骨髓衍生抑制细胞 (MDSCs) 是不成熟的骨髓细胞,会影响肝脏稳态和疾病进展.
- MDSC与肝细胞和调节性T细胞相互作用,影响肝病的结果.
研究的目的:
- 探索MDSCs在肝病病原和进展中的多方面的作用.
- 确定MDSC作为各种肝病的潜在治疗点,包括癌症和自身免疫性肝炎.
- 讨论在肝病治疗中针对MDSCs的挑战和未来方向.
主要方法:
- 对肝病中MDSC功能现有文献的综述.
- 分析调节MDSC透和激活的因素 (化学因子,细胞因子,纤维细胞,表观遗传学,肠道微生物群).
- 讨论治疗策略和针对MDSCs的挑战.
主要成果:
- MDSCs是肝脏内先天性和适应性免疫反应的关键调节者.
- 在肝损伤和癌症期间,MDSC透和激活受到多种因素的影响.
- 针对MDSCs显示出治疗肝癌,肝脏再生,酒精/非酒精性肝病和自身免疫性肝炎的前景.
结论:
- MDSCs在肝脏疾病的发病和进展中起着关键作用.
- 克服像表型异质性和缺乏特定标志物的挑战对于有效的MDSC向疗法至关重要.
- 建议进行多项OMIC研究,以确定特定疾病的MDSC特征和治疗点.
相关概念视频
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
Liver Physiology
547
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
547
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K


