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治疗疼痛的四大麻素和大麻素-关于证据的更新

Kawthar Safi¹, Jan Sobieraj¹, Michał Błaszkiewicz¹

¹Palliative Medicine Clinic, Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland.

|February 24, 2024

概括

大麻素显示出治疗慢性疼痛的潜力,包括神经病和癌症疼痛,特别是当与阿片类药物一起使用时. 然而,根据目前的指导方针,需要更多的研究来确认它们的有效性和安全性.

科学领域:

疼痛管理疼痛管理
药理学药理学是指药理学的学科.
神经学神经学

背景情况:

目前国际疼痛研究协会 (IASP) 的临床实践指南 (CPG) 和欧洲医学瘤学会 (ESMO) 的指南强调了围绕使用大麻素治疗疼痛的争议.
由于与阿片类药物的协同作用,大麻素可以提供潜在的疼痛缓解,可能减少呼吸系统抑郁.
有限的研究存在,但大麻素可以缓解成年人的特定慢性疼痛亚型,包括神经病,肌肉骨,癌症和老年疼痛.

研究的目的:

对神经性疼痛中的大麻素进行当前的临床前和临床研究进行审查.
讨论大麻素在慢性癌症疼痛和多发性硬化症和头痛等非癌症疾病中的作用.
探索基于大麻素的治疗疼痛的新的施用技术和作用机制.

主要方法:

对现有的临床前和临床研究进行系统审查.
对处理神经病痛环境中的各种大麻素类型的研究进行分析.
包括关于慢性癌症疼痛和非癌症疾病的研究.

主要成果:

大麻素在治疗特定慢性疼痛亚型方面表现有前途,包括神经病痛和化疗诱导的周围神经病变 (CIPN).
对于艾滋病毒相关的神经病痛和老年人腰部疼痛,假设有潜在的止痛益处.
大麻素可能与阿片类药物提供辅助益处,可能减轻呼吸系统抑郁.

结论:

尽管有潜在的益处,但由于研究不足,使用大麻素来治疗疼痛仍然存在争议.
需要进一步进行高质量的研究,以制定关于在疼痛管理中使用大麻素的明确指导方针.
大麻素为各种慢性疼痛疾病提供了潜在的治疗途径,需要继续进行研究.

关键词:

在Cannabidiol中使用.大麻素是一种大麻素.纳比克西莫尔斯 (nabiximols) 是一个古老的先知.神经病变性疼痛是一种神经性疼痛.无感觉性疼痛是一种疼痛感.这是一种四化大麻醇 (tetrahydrocannabinol).

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