附录的特点和COVID-19儿童尾炎发展的特征
Grigory Demyashkin1,2, Konstantin Gorokhov1, Vladimir Shchekin2
1Department of Pathomorphology, National Medical Research Centre of Radiology, Ministry of Health of Russia, 249036 Obninsk, Russia.
儿童的COVID-19感染会导致尾炎,造成破坏性变化,尾中免疫细胞和细胞因子增加. 这些SARS-CoV-2影响在6-12岁儿童中最严重.
科学领域:
- 儿科病理学 儿科病理学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 研究SARS-CoV-2对儿科恒温的影响至关重要.
- 患有COVID-19的儿童尾的病态变化需要进一步研究.
研究的目的:
- 在不同年龄组的COVID-19儿童中进行尾的形态和分子生物学评估.
主要方法:
- 将三个组进行比较:COVID-19患者 (n=42),急性尾炎患者 (n=55,大流行前) 和对照组 (n=38).
- 通过免疫细胞 (CD3,CD4,CD68,CD163,CD20,CD138) 和细胞因子 (IL-1,IL-6,IL-4,IL-10) 的抗体进行了组织学和免疫组织化学分析.
主要成果:
- 受到COVID-19影响的尾显示具有破坏性的性和性尾炎.
- 在COVID-19病例中观察到CD3+,CD4+,CD68+,CD163+,CD20+和CD138+细胞的增加.
- 检测到高水平的促炎性 (IL-1,IL-6) 和抗炎性 (IL-4,IL-10) 细胞因子.
结论:
- 病理和免疫组织化学变化在6-12岁儿童中最为明显.
- COVID-19显著影响了儿童的尾形态和免疫反应.
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