皮质醇对急性心理社会压力的反应在医生倦怠中
Claudia Zuccarella-Hackl1, Mary Princip1, Sarah A Holzgang1
1Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Haldenbachstrasse 16/18, CH-8091 Zurich, Switzerland.
Biomedicines
|February 24, 2024
概括
经历倦怠的男性医生在压力测试期间表现出较高的皮质醇反应. 这表明慢性压力的潜在生理标志物,影响心血管健康和应激反应机制.
科学领域:
- 内分泌学和压力生理学生理学
- 职业健康心理学 职业健康心理学
- 心血管健康研究 心血管健康研究
背景情况:
- 医生倦怠是一个重要的职业健康问题,由情绪疲劳,非个性化和由于慢性工作压力而减少个人成就来定义.
- 了解倦怠的生理基础对于开发有效的干预措施和管理其对医生福祉和心血管健康的影响至关重要.
研究的目的:
- 在急性心理社会压力测试期间,研究和比较男性医生中皮质醇反应的燃烧与健康对照.
- 探讨燃烧程度,特别是情绪疲劳和皮质醇应激反应之间的关系.
主要方法:
- 2019年9月至2021年12月期间,一项涉及60名男性医生 (30名患有倦怠,30名健康对照) 的横截面研究.
- 唾液皮质醇水平在特里亚社会压力测试 (TSST) 之前和之后被测量.
- 使用Maslach Burnout Inventory-Human Services Survey (MBI-HSS) 评估燃烧情况;用重复测量和曲线分析下的面积分析数据.
主要成果:
- 患有倦怠症的男性医生在TSST后表现出显著更大的皮质醇反应性,特别是在紧张后的即时阶段 (0-15分钟).
- 情绪疲劳的较高水平与皮质醇比基线增加和皮质醇下降后压力下降相关.
结论:
- 在患有倦怠症的男性医生中,皮质醇反应性升高可能表明慢性压力适应的初始阶段.
- 这些发现强调了在医生倦怠和其潜在的长期心血管影响的背景下,考虑皮质醇在生理应激反应中的作用的重要性.
- 建议进行进一步的纵向研究,以阐明皮质醇对不同人群压力反应和心血管健康的影响.
相关概念视频
Introduction to Stress and Lifestyle
111
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
111
Hypothalamic-Pituitary Axis
60.0K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.0K
Physiological Foundation of Stress
58
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
58
Psychological Responses to Stress
54
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
54
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Stress and Mental Health
157
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
157


