植物单烯和精油作为潜在的抗衰老剂:从临床前数据的见解
Mónica Zuzarte1,2,3, Cátia Sousa4,5, Jorge Alves-Silva1,2,3
1Univ Coimbra, Faculty of Pharmacy, Azinhaga de S. Comba, 3000-548 Coimbra, Portugal.
Biomedicines
|February 24, 2024
概括
来自芳香植物的挥发性单烯通过向衰老的标志,显示出潜在的抗衰老作用. 本综述系统化了它们的机制,并为未来的治疗策略确定了研究缺口.
科学领域:
- 老年病学和药理学.
- 自然产品化学 自然产品化学
背景情况:
- 老龄化是一个自然过程,与生理衰退和主要疾病风险增加有关.
- 确定改善健康和寿命的目标是一个不断增长的研究领域.
- 芳香植物是生物活性化合物的公认来源,特别是挥发性单烯,据报道具有抗衰老特性.
研究的目的:
- 系统地审查挥发性单烯的抗衰老潜力.
- 为了将单烯活性与特定的衰老特征联系起来.
- 阐明作用机制和化学结构-活性关系.
主要方法:
- 文献审查和现有研究的系统化.
- 挥发性单烯的分类基于它们对衰老特征的影响.
- 分析已识别的机制和结构-活动关系.
主要成果:
- 挥发性单烯表现出与衰老特征相关的多种生物活性.
- 特定的单烯在向细胞衰老,氧化应激和线粒体功能障碍方面表现有前途.
- 确定的机制包括抗氧化,抗炎和表观遗传调节.
结论:
- 挥发性单烯是开发抗衰老干预措施的有希望的自然化合物类别.
- 需要进一步的研究来探索特定的单烯,它们的精确机制和临床应用.
- 本综述突出了研究缺口,并为以天然产品为基础的地球科学未来研究提供了基础.
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