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在COVID-19患者的肌肉功能障碍和功能状态在疾病期间和出院后

Otakar Psenicka^1,2, Tomas Brutvan^1,2, Jan Kratky^1,2

¹3rd Department of Internal Medicine, General University Hospital, 120 00 Prague, Czech Republic.

|February 24, 2024

概括

COVID-19肺炎导致显著的肌肉损失和降低生活质量,甚至在出院六个月后. 对大腿肌肉厚度的超声波测量可以有效地监测患者的肌肉损耗.

科学领域:

医学科学医学科学医学科学
肺部病理学肺部病理学
康复医学康复医学康复医学

背景情况:

COVID-19 肺炎与系统性炎症反应综合征 (SIRS) 和过度代相关.
在COVID-19的急性阶段发生显著的肌肉损失 (骨髓缩症).
退院患者肌肉消耗的长期影响需要评估.

研究的目的:

在急性COVID-19肺炎期间量化肌肉质量减少.
评估医院出院后患者的长期功能后续.
探索肌肉质量,功能状态和生活质量之间的相关性.

主要方法:

研究了16名患有COVID-19肺炎和呼吸不全的患者队列.
测量包括体重,BMI,瘦身量 (LBM),白蛋白,CRP,NLR,超声波评估的大腿肌肉厚度 (美国RF和美国RF+VI),手握强度,EQ-5D生活质量和巴特尔的ADLs.
数据是在入院,放学和放学后1,3个月和6个月收集的.

主要成果:

在入院和出院之间观察到大腿肌肉厚度 (美国RF,美国RF + VI),生活质量 (EQ-5D) 和日常生活活动 (ADL) 的显著减少.
在大腿肌肉厚度 (美国RF+VI) 和手握强度之间发现了正相关性.
在体重和巴特尔指数之间观察到负相关性;在随访期间,肌肉功能与EQ-5D和ADL相关.

结论:

在住院期间,COVID-19肺炎导致肌肉质量显著减少.
在出院后的6个月内,与健康有关的生活质量大幅下降,主要是由于肌肉损失.
对大腿肌肉厚度的超声波测量是监测COVID-19患者肌肉损失的宝贵工具.

关键词:

在 COVID-19 疫情中,危急的疾病危急的疾病.从长远来看,这些都是长期的结果.肌肉超声波肌肉超声波是一种超声波.人们的生活质量.

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