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局部疗法的价值在先进的皮上腺癌中
Otilia Kimpel1, Barbara Altieri1, Marta Laganà2
1Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, University of Würzburg, 97070 Würzburg, Germany.
Cancers
|February 24, 2024
概括
像局部热移除 (LTA) 这样的局部疗法显示了高级上腺皮层癌 (ACC) 的高局部疾病控制,支持当前的治疗指南.
科学领域:
- 在瘤学瘤学.
- 干预性放射学 干预性放射学
背景情况:
- 国际指导方针建议针对晚期上腺皮层癌 (ACC) 进行局部治疗 (LTs).
- 支持LTs这些建议的证据有限,包括局部热切除除 (LTA),跨动脉 (化学) 栓塞 (TAC) 和跨动脉放射栓塞 (TARE).
- 这项研究回顾性地分析了晚期治疗在晚期ACC患者中的疗效和结果.
研究的目的:
- 评估局部疗法 (LTs) 在治疗晚期上腺皮层癌 (ACC) 的有效性.
- 评估治疗病变进展的时间 (tTTP),客观反应率,生存率和不良事件.
- 为了确定治疗成功的预测因素,先进的ACC患者接受LTs.
主要方法:
- 对66名晚期ACC患者的回顾性分析,这些患者接受了LTs治疗 (LTA,TA,C) E,TARE).
- 评估了132个瘤病变,重点关注治疗病变进展的时间 (tTTP) 作为主要终点.
- 使用多变量考克斯分析来确定预测结果的预测因素.
主要成果:
- 在LTs中观察到高局部疾病控制率.
- 与TA(C) E和TARE相比,局部热除 (LTA) 显示出更好的进展时间.
- 在41%的治疗病变中实现了完全或部分响应,而LTA是完全响应的唯一原因.
结论:
- 局部疗法,特别是LTA,在实现高级ACC的高局部疾病控制方面是有效的.
- 这些发现支持当前的国际准则建议,建议在先进的ACC中使用语言技术.
- 不到四次前期治疗和足够的米托坦水平等因素对治疗结果产生了积极的影响.
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