液体制剂与甲状腺细针吸血体中的常规涂抹的比较:系统性审查和元分析
Yun Jin Kang1, Hyeon Woo Lee1, Gulnaz Stybayeva2
1Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan 14584, Republic of Korea.
Cancers
|February 24, 2024
概括
传统的涂抹 (CSs) 和液体制剂 (LBPs) 对甲状腺病变的诊断准确度相似. 然而,SurePath LBPs与ThinPrep LBPs相比显示出更高的诊断性能,这表明它是首选的方法.
科学领域:
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
- 诊断的准确性 诊断的准确性
背景情况:
- 甲状腺结节很常见,对恶性瘤的准确诊断至关重要.
- 传统的涂抹 (CSs) 和基于液体的制剂 (LBPs) 是甲状腺细针吸收细胞学的常见方法.
- 将CS和LBP的诊断性能进行比较对于优化患者护理至关重要.
研究的目的:
- 为了比较常规涂抹 (CSs) 和液体制剂 (LBPs) 对甲状腺病变的诊断准确性.
- 为了评估不同类型的LBP的性能,特别是ThinPrep和SurePath.
主要方法:
- 系统审查和对2023年12月之前发表的研究进行元分析.
- 包括17项研究,包括15861个甲状腺细针吸取样本.
- 分析了诊断几率比 (DOR),接收器运行特征曲线 (AUC) 下的面积,灵敏度,特异性以及不充分的标本率.
主要成果:
- 在CS和LBP之间,诊断准确度或不充分的涂抹率没有显著差异.
- 与ThinPrep LBPs (0.865) 相比,SurePath LBPs显示出明显更高的AUC (0.879) 与ThinPrep LBPs (0.865) 相比.
- 单个方法 (CS和LBP) 的诊断几率比联合CS加LBP方法更高.
结论:
- CS和LBP都有效诊断甲状腺病变,准确度相似.
- SurePath基于液体的制剂比ThinPrep提供了更高的诊断准确性.
- 未来关于精细针吸入细胞学的建议应该平衡成本,可行性和诊断准确性.
相关概念视频
Sampling Methods: Sample Types
Sampling materials are classified into three main types: solid, liquid, and gas.
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
Solid samples include a variety of substances, such as sediments from water bodies, soil, metals, and biological tissues. Two standard methods for extracting sediments from water bodies are grab sampling and piston coring. Grab sampling involves using a device to collect a discrete sediment sample from the bottom of a water body with minimal disturbance. Grab samples do not always represent the entire area due to...
Atomic Absorption Spectroscopy: Lab
For AAS measurements, samples must be introduced as clear solutions, often requiring extensive preliminary treatment to dissolve materials like soils, animal tissues, and minerals. Common methods for sample preparation include treatment with hot mineral acids, wet ashing, combustion in closed containers, high-temperature ashing, or fusion with reagents.
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing nebulizer...
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing nebulizer...
Methods for Studying Drug Absorption: In situ
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...


