基于人口的结肠直肠查计划中的间隔癌症:瘤的发生率和特征
Mercedes Vanaclocha-Espí1, Marina Pinto-Carbó1, Josefa Ibáñez1,2
1Foundation for the Promotion of Health and Biomedical Research in the Valencian Community (FISABIO)-Public Health, 46020 Valencia, Spain.
Cancers
|February 24, 2024
概括
在结直肠癌 (CRC) 查中,间隔癌症 (IC) 通过免疫化学测试 (FIT) 与瓜亚克测试 (gFOBT) 相比减少. 男人和老年人面临更高的IC风险,而定期查参与降低了它.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 查计划 查计划
背景情况:
- 在结直肠癌 (CRC) 查中,间隔癌症 (IC) 指的是在负面查测试之间诊断出的癌症.
- 了解IC发病率和风险因素对于优化CRC查计划有效性至关重要.
- 基于瓜亚克的便隐性血液测试 (gFOBT) 和免疫化学便测试 (FIT) 是常见的查方式.
研究的目的:
- 在接受结直肠癌查的大群中评估间隔癌症 (IC) 率和相关风险因素.
- 为了比较瓜亚克 (gFOBT) 和免疫化学 (FIT) 便隐性血液测试在检测IC的性能.
- 分析间隔癌症 (IC) 与查癌症 (SC) 的特征.
主要方法:
- 一项后续研究分析了西班牙四个CRC查计划中的664,993名参与者的数据.
- 计算的IC和查检测癌症 (SC) 率为gFOBT和FIT.
- 采用考克斯回归来确定IC风险因素和嵌病例对照研究来比较瘤特征.
主要成果:
- 与gFOBT (1.16) 相比,FIT (0.35) 的IC率明显较低.
- 在男性 (HR=1.81) 和60-69岁 (HR=1.95) 个体中观察到IC概率增加.
- 定期查参与降低了IC概率 (HR=0.62),FIT中较高的Hb检测与IC风险增加相关. 瘤更大,更先进,主要是脑部瘤.
结论:
- 免疫化学便测试 (FIT) 在降低间隔癌 (IC) 在结肠直肠癌 (CRC) 查中的发病率方面表现优异,与瓜亚克测试 (gFOBT) 相比.
- 风险分层识别男性,老年人,以及具有更高FIT检测血红蛋白水平的人,可以为有针对性的查策略提供信息.
- 定期参加查计划与间隔癌症风险降低有关,这突显了遵守计划的重要性.
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