在接受多模式治疗的晚期胃癌患者中,炎症负担指数的预后值
Zuzanna Pelc1, Katarzyna Sędłak1, Radosław Mlak2
1Department of Surgical Oncology, Medical University of Lublin, 20-080 Lublin, Poland.
炎症负担指数 (IBI) 显示了作为胃癌 (GC) 患者预后生物标志物的潜力,预测了经过多式治疗的中欧人口的并发症和死亡率.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 炎症研究的研究.
背景情况:
- 系统性炎症在致癌过程中起着关键作用.
- 炎症负担指数 (IBI) 是癌症患者生存的潜在生物标志物.
- 此前,IBI仅在东部胃癌 (GC) 患者中得到验证.
研究的目的:
- 评估在接受多模式治疗的中欧GC患者中IBI的预后价值.
- 评估IBI与术后并发症和死亡率之间的关联.
- 为了比较IBI的预后意义与其他既定的标记物,如中性粒细胞与淋巴细胞比率 (NLR).
主要方法:
- 在2013年至2021年期间接受治疗的93名组织学确认的GC患者的回顾性分析.
- 新辅助化疗 (NAC) 的标准化和手术前采集血液样本.
- 使用教科书结局 (TO) 和使用瘤回归等级 (TRG) 的NAC反应来评估外科质量.
主要成果:
- 较高的IBI与术后并发症风险增加显著相关 (OR2.95).
- 在多变量分析中,高IBI (HR = 2.56) 和高NLR (HR = 2.55) 预测死亡风险增加.
- 接受NAC (HR = 0.40) 和获得TO (HR = 0.42) 与降低死亡率有关.
结论:
- IBI是经过多式疗法治疗的胃癌患者的宝贵预后生物标志物.
- 在这个患者队列中,IBI与术后并发症和整体死亡率有关.
- IBI需要进一步的研究,作为在不同胃癌群体中的预测工具.
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