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在使用无透的Perceval S生物假体进行大动脉置换的患者中发生血栓缺血:一项回顾性研究

Adrien Jayet¹, Henri Lu², Pierre Monney²

¹Division of Cardiovascular Surgery, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.

Journal of clinical medicine

|February 24, 2024

概括

与Trifecta相比,Percival S生物假体在动脉置换后会导致更严重的血小板缺血 (血小板数量低). 然而,这并没有导致接受Perceval S门的患者的短期结果更差.

科学领域:

心血管外科心血管外科
血液学血液学血液学
生物材料科学生物材料科学

背景情况:

手术后的血小板缺血是与无的Perceval S生物假体相关的已知并发症.
了解血小板缺血的比较发病率和严重程度对于在动脉置换 (AVR) 后的患者管理至关重要.

研究的目的:

用Perceval S或Trifecta生物假体来比较AVR后血小板缺血的发生率,严重程度和临床影响.
评估二次结果,包括血液溶解,炎症标志物和临床/心声检查结果.

主要方法:

在2016年3月至2019年8月期间接受AVR的156名患者的回顾性分析.
主要终点:手术后15天内血小板数最少.
二级终点:术后血解,炎症标志物 (乳酸脱酶,C反应蛋白,白细胞),临床结果和心声回声数据.

主要成果:

与Trifecta组 (n=53) 相比,Perceval S组 (n=103) 的血小板数显著减少.
手术后的血小板缺血在Perceval S组中更为严重 (最差:89.2 ± 37.7 × 10^9/L与106.5 ± 34.1 × 10^9/L相比,p=0.01).
两组之间在血解标志物,炎症参数,30天死亡率,住院或重新手术率方面没有发现显著差异.

结论:

在AVR之后,Perceval S生物假体与更严重的术后血小板缩有关.
尽管血小板缺血增加,但与Trifecta生物假体相比,Perceval S并没有导致较高的短期发病率或死亡率.

关键词:

佩尔塞瓦尔S门的使用情况大动脉门更换术生物假体生物假体没有的无.血小板细胞减少症 (Thrombocytopenia) 是一种

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