维生素D水平作为严重SARS-CoV-2感染的标志物
Lambros Athanassiou1, Ifigenia Kostoglou-Athanassiou2, Sofia Nikolakopoulou1
1COVID-19 Department, Asclepeion Hospital, Voula, GR16673 Athens, Greece.
Life (Basel, Switzerland)
|February 24, 2024
概括
维生素D缺乏在严重的SARS-CoV-2感染中很常见,并且与更糟糕的结果有关. 较低的维生素D水平与住院患者的炎症标志物增加和死亡率相关.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 严重的SARS-CoV-2感染呈现出各种临床症状.
- 维生素D具有免疫调节作用,可能会增强免疫系统对抗病原体.
研究的目的:
- 为了评估25-氧维生素D3 (25(OH) D3) 水平,在住院的病人严重的SARS-CoV-2感染.
- 调查25(OH) D3水平与患者的治疗结果之间的关联.
主要方法:
- 在88名患有严重SARS-CoV-2感染的住院患者和匹配的对照组中分析了25...OH) D3水平.
- 统计分析包括学生的t测试,奇方测试,费舍尔的精确测试和线性回归.
主要成果:
- 与对照组 (24.34 ± 10.34 ng/mL) 相比,患有严重的SARS-CoV-2感染的患者的25(OH) D3水平显著降低 (17.36 ± 8.80 ng/mL).
- 维生素D缺乏和不足与较高的死亡率有关.
- 较低的25(OH) D3水平与C-反应蛋白,费里丁,d-二聚合物和纤维素素相反相关.
结论:
- 在严重的SARS-CoV-2感染中,维生素D缺乏很普遍.
- 低25 ((OH) D3水平与住院患者的不良结果有关,包括增加死亡率和炎症标志物.
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