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乳腺细胞系中葡萄藤提取物的抗氧化和抗癌活性

Evgenia Maria Tsantila¹, Nils Esslinger², Maria Christou³

¹Apoptosis and Cancer Chemoresistance Laboratory, Basic and Translational Cancer Research Center, Department of Life Sciences, European University Cyprus, Nicosia 2404, Cyprus.

Life (Basel, Switzerland)

|February 24, 2024

概括

葡萄种子提取物从Vitis vinifera显示强大的抗氧化和抗癌性质. 这些天然化合物有效地抑制反应性氧物种,并在不伤害正常细胞的情况下诱导乳腺癌细胞的亡.

科学领域:

植物化学植物化学
药理学药理学是指药理学的学科.
在瘤学瘤学.

背景情况:

葡萄藤 (葡萄) 提取物富含多,具有抗氧化和潜在的抗癌活性.
以前的研究表明,葡萄提取物对包括癌症在内的各种疾病具有治疗效益.

研究的目的:

为了生产和描述来自不同植物部位 (种子,水果,叶子,木材) 的Vitis vinifera提取物.
评估这些提取物对正常和乳腺癌细胞系的抗氧化和抗增殖作用.
为了确定最强效的提取物,并阐明其对抗乳腺癌的作用机制.

主要方法:

使用不同的方法提取12个Vitis vinifera Airen品种样本.
总多含量量 (TPC) 的量化.
对抗氧化活性 (ROS抑制) 和对正常细胞的细胞毒性进行评估.
对乳腺癌细胞系的抗增殖作用的评估和与亡相关的蛋白质表达的分析 (Bcl-2,Bcl-xL,survivin).

主要成果:

葡萄种子提取物比其他植物部位的提取物表现出更高的TPC.
大多数种子提取物表现出抗氧化活性,并没有对正常乳腺细胞的细胞毒性.
来自全有机白葡萄种子的提取物显示出最佳的ROS抑制和对MCF-7细胞的抗增殖作用,通过抑制Bcl-2,Bcl-xL和生存,诱导细胞亡.

结论:

葡萄酒种子提取物具有显著的抗氧化和抗增殖特性.
鉴定出的白葡萄种子提取物是乳腺癌治疗的有希望的候选者.
对葡萄酒成分的进一步研究可能会开启新的药理学应用.

关键词:

葡萄酒 (Vitis vinifera) 是一种葡萄酒.抗氧化剂抗氧化剂是一种抗氧化剂.乳腺癌乳腺癌乳腺癌化学预防化学预防干种子提取物干种子提取物天然的抗癌药物,自然的抗癌药物.聚醇是一种多醇.有活性氧物种的反应性氧物种.白葡萄是一种白葡萄.白葡萄的提取物白葡萄的提取物

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