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在基于正念的慢性疼痛疼痛的疼痛管理中,催产素调节

Oytun Aygün¹, Emily Mohr², Colin Duff³

¹Laboratoire DysCo, Université Paris 8 Vincennes-Saint-Denis, 93526 Saint-Denis, France.

Life (Basel, Switzerland)

|February 24, 2024

概括

基于正念的疼痛管理显著增加了慢性疼痛患者的催产素水平,改善了疼痛感知和情绪. 这表明催产素通路是非药物治疗疼痛的关键.

科学领域:

神经科学是一个神经科学.
心理学心理学心理学
免疫学免疫学免疫学

背景情况:

治疗慢性疼痛的阿片类药物治疗有成和滥用风险.
非药理学方法,如基于正念的疼痛管理 (MBPM) 提供了替代方案.
了解MBPM的机制对于有效的疼痛管理至关重要.

研究的目的:

为了研究8周的MBPM干预对慢性疼痛的影响.
检查MBPM对炎症标志物,压力生理学和催产素水平的影响.
探索这些生理变化与临床疼痛症状之间的相互作用.

主要方法:

一项机制性临床研究,将MBPM与等待列表对照组进行比较.
包括50名慢性疼痛患者和15名健康对照.
唾液检测内分泌标记物,催产素,细胞因子 (IL-1b,IL-6,IL-8,TNF-a) 和脱水二二酸盐 (DHEA-S) 的唾液检测.
对疼痛感知,正念,情绪和幸福感的心理评估.

主要成果:

与健康对照组相比,慢性疼痛患者表现出显著的心理痛苦.
干预MBPM导致患者的催产素水平显著增加.
细胞因子和DHEA-S水平呈现下降趋势,表明潜在的抗炎作用.
心理评估显示,MBPM组的疼痛感知和情绪显著改善.

结论:

在改善慢性疼痛感知和情绪方面,MBPM有效.
催产素通路似乎在MBPM的治疗效果中发挥着重要作用.
虽然压力标志物 (DHEA-S) 减弱,但主要的疼痛减轻可能不仅仅与压力有关.
催产素的作用需要进一步研究,作为慢性疼痛管理中的治疗点.

关键词:

慢性疼痛是一种慢性疼痛.细胞因子细胞因子内分泌系统内分泌系统正念是一种正念的状态.催产素是一种催产素.压力生理学压力生理学

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