阻塞性睡眠呼吸暂停的成年人中维生素D状况和多睡眠学参数之间的关联
Ioanna Kechribari1, Meropi D Kontogianni1, Michael Georgoulis1
1Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens, 17676 Athens, Greece.
Life (Basel, Switzerland)
|February 24, 2024
概括
维生素D缺乏与严重阻塞性睡眠呼吸暂停 (OSA) 有关. 维生素D水平较低会增加严重OSA的几率,特别是在老年人和肥胖患者中,这表明维生素D状态对OSA管理很重要.
科学领域:
- 睡眠医学 睡眠医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍.
- 维生素D缺乏症 (VDD) 和OSA严重程度之间的关系尚未完全理解.
- VDD可能在OSA的病理生理学或恶化中发挥作用.
研究的目的:
- 为了研究血清25-基维生素D [25(OH) D]水平与被诊断为OSA的成年人中的多睡眠学参数之间的关联.
- 探索VDD与OSA严重程度之间的关系.
- 确定OSA患者的子组,其中VDD可能是严重程度的重要预测因素.
主要方法:
- 一项涉及262名通过多睡眠学诊断患有OSA的成年人的横截面研究.
- 数据收集包括人口统计,病史,人体测量,生活方式和血清25(OH) D水平.
- 统计分析包括相关性,逻辑回归和分层分析,并对潜在的混因素进行调整.
主要成果:
- 在63%的参与者中存在维生素D缺乏 (25(OH) D <20 ng/mL).
- 较低的血清25(OH) D水平与OSA严重性指数负相关,包括呼吸暂停-呼吸暂停指数.
- VDD与严重OSA的几率大约高出三倍,特别是在50岁以上的参与者和体重指数≥30kg/m2的参与者中.
结论:
- 这项研究提供了维生素D水平与OSA严重程度之间的反向关联的证据.
- 在特定的子组中,VDD是严重OSA的独立风险因素.
- 维生素D的状态应被认为是阻塞性睡眠呼吸暂停综合管理的潜在可修改因素.
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