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缺乏会减少骨质,但不会影响卵巢切除的老鼠的肥胖,这些老鼠被养高脂肪饮食
1USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202, USA.
Nutrients
|February 24, 2024
概括
缺乏和高脂肪饮食独立地损害了卵巢切除的老鼠的骨结构. 在这项研究中,食中的和脂肪含量都没有影响身体成分或脂肪度.
科学领域:
- 骨生物学 骨生物学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 由于高脂肪 (HF) 饮食导致的肥胖会损害骨质量和强度.
- (Ca) 摄入量是骨质疏松症和肥胖症的可修改因素.
- 卵巢切除 (OVX) 的老鼠是绝经后骨质损失的一个模型.
研究的目的:
- 研究Ca缺乏和HF饮食对OVX大鼠骨结构和脂肪的独立和联合影响.
- 为了测试Ca缺乏会加剧骨损失和增加脂肪质量的假设,HF养的OVX大鼠.
主要方法:
- 47只OVX大鼠被养2x2因子饮食:正常脂肪 (NF) 或高脂肪 (HF) 低卡路里 (LC) 或正常卡路里 (NC) 4个月.
- 一组对照组由12只假操作的老鼠组成,接受了NFNC饮食.
- 分析了骨结构 (BV/TV,Tb.N,Tb.Sp,BMD) 和身体组成 (脂肪质量,瘦肉质量).
主要成果:
- LC显著降低了骨体积/总体积 (BV/TV),连接密度,状骨数 (Tb.N),骨矿物密度 (BMD) 和状骨分离 (Tb.Sp) 的增加.
- 与NF饮食相比,HF饮食导致BV/TV和Tb.N降低,但体重,脂肪量,Tb.Sp和血清瘦素增加.
- 对于身体组成或骨参数,没有发现Ca和脂肪含量之间的显著相互作用. 甲酸缺乏没有影响脂肪.
结论:
- 摄入不够的和HF饮食对OVX大鼠的骨结构产生独立的有害影响.
- 在接受HF饮食的OVX大鼠中,Ca缺乏不会加剧脂肪.
- OVX手术本身损害了椎骨结构,独立于饮食因素.
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