怀孕期间肠道微生物群和便和血清代谢的动态 - 一项纵向研究
Ruili Pan1,2, Min Guo1,2, Ying Chen1,2
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Nutrients
|February 24, 2024
概括
怀孕改变了肠道微生物群和代谢物,在整个孕期和产后观察到不同的微生物群落和代谢变化. 一个协调的网络将这些变化联系在一起,影响母亲的健康和胎儿的发育.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 人体生理学 人体生理学
背景情况:
- 怀孕涉及显著的生理适应,包括荷尔蒙,免疫和代谢变化.
- 建议肠道微生物群在怀孕中的作用,但尚未完全理解,关于其动态变化和代谢物相互作用的发现不一致.
研究的目的:
- 在怀孕和产后期间纵向描述肠道微生物群,Bifidobacterium群落和血清/便代谢组的时间动态.
- 澄清肠道微生物群与怀孕期间动态代谢变化之间的关系.
主要方法:
- 肠道微生物群组成和Bifidobacterium社区的纵向分析.
- 血清和便代谢组的全面分析.
- 在怀孕期间和产后31名妇女的微生物和代谢数据之间的相关性分析.
主要成果:
- 在怀孕期间和产后观察到不同的肠道微生物组成,在Lachnospiraceae和Ruminococcaceae家族中出现了显著的变化.
- 动态的代谢变化包括关键营养素 (酸),抗炎化合物 (转-3-烯酸) 和类固醇激素 (孕激素).
- 在与怀孕相关的微生物群和代谢物之间确定了一个复杂的相关网络,特定的品种有助于代谢物变化.
结论:
- 一个协调的微生物群-代谢物调节网络似乎对怀孕过程至关重要.
- 这些发现增强了对怀孕期间分子过程的理解,为营养和健康管理提供了信息.
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